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Cancer centers say US chemotherapy shortage is leading to treatment complications

Cancer centers say US chemotherapy shortage is leading to treatment complications
HOW IT’S AFFECTING PATIENTS. IN THE SAME YEAR HE TURNED 50 YEARS OLD. MICHAEL GRIFFITH STARTED HAVING PAIN. I WENT INTO THE DOCTOR AND ABOUT SIX HOURS LATER, AFTER A NUMBER OF TESTS, THEY THEY LET ME KNOW THAT IT WAS A STAGE FOUR. COLANGELO CARCINOMA, AN AGGRESSIVE FORM OF BILE DUCT CANCER IN HIS LIVER WITH TUMORS THROUGHOUT HIS BODY. THEY IMMEDIATELY BEGAN CHEMOTHERAPY AND THE TUMORS STARTED TO SHRINK. SO WE’VE BEEN ON THIS GREAT PATH WITH THE IMMUNOTHERAPY AND THE TWO OTHER DRUGS, THE GEMCITABINE AND THE CISPLATIN. BUT THIS SPRING, THAT TREATMENT CHANGED. THEY SAID, HEY, BY THE WAY, DON’T KNOW IF YOU KNOW, BUT THERE’S A SHORTAGE ON CISPLATIN, SO YOU’RE ONLY GETTING GEMCITABINE TODAY. OKAY. ALL RIGHT. I YOU KNOW, I THINK I’M DOING PRETTY GOOD. SO THAT’S FINE. AND I DON’T HAVE ANY CONTROL OVER IT. SO LET’S DO THIS. BUT THIS HAPPENED OVER AND OVER. AND AFTER A TRIP TO THE E.R. THIS MONTH, THEY FOUND HIS CANCER IS ONCE AGAIN GROWING. THE ONLY THING THAT’S CHANGED, THE LACK OF CISPLATIN. YOU KNOW, MAYBE SOME PEOPLE ARE LOOKING AT THIS AS A BREAK, YOU KNOW, LIKE, OKAY, I CAN TAKE A BREAK FROM THIS DRUG, BUT THEY’RE NOT BEING TOLD WHAT’S GOING TO HAPPEN IF THEY DO TAKE A BREAK AND THEY’RE JUST BEING TOLD LIKE THERE’S NOTHING YOU CAN DO. SO THIS JUST IS WHAT IT IS. AND NOBODY’S ASKING QUESTIONS. WHY IS IT THAT THIS IS HAPPENING? THE FDA HAS CISPLATIN ALONG WITH FIVE OF ITS MANUFACTURERS, LISTED AS A DRUG IN CURRENT SHORTAGE WITH REASONS FROM BACK ORDERING TO LIMITED SUPPLY AND DEMAND INCREASE. MICHAEL IS GETTING TREATMENT LOCALLY WITH KAISER PERMANENTE, WHO TOLD US THEY, ALONG WITH OTHER PROVIDERS, ARE CURRENTLY EXPERIENCING A NATIONWIDE SHORTAGE. THIS SHORTAGE IS IMPACTING ALL PHARMACIES IN THE UNITED STATES. THE SHORTAGE IS A RESULT OF NUMEROUS FACTORS, INCLUDING THE CLOSURE OF A MAJOR MANUFACTURING PLANT DUE TO OPERATIONAL ISSUES IDENTIFIED BY THE FDA. KAISER PERMANENTE GOING ON TO SAY AT THIS TIME THERE IS NO DEFINITIVE INFORMATION ON WHEN SUPPLY OF CISPLATIN WILL RETURN TO PRE SHORTAGE LEVELS WITH SOMETHING THAT IS IN SUCH DEMAND AND CONSCIOUS. ONLY IF YOU DEVELOP A DRUG LIKE THAT, WOULDN’T YOU WANT TO MAKE MORE OF IT KNOWING THAT YOU’RE DOING ALL THIS GOOD, GIVEN NO MEDICAL ALTERNATIVE TO THE DRUGS CISPLATIN AT THIS TIME? MICHAEL AND HIS FIANCE NIKKI NOW FIGHT TO UNDERSTAND WHY THIS SHOULDN’T BE HAPPENING. THIS CAN BE STOPPED. CANCER IS TREATABLE IN SOME CASES IT’S CURABLE. AND WITHOUT THESE DRUGS, THERE’S NOTHING ANYBODY CAN DO ABOUT IT. AND SO WE HAVE TO FIGHT FOR OURSELVES, FOR OTHER PEOPLE. WE HAVE TO MAKE THIS MORE WIDELY KNOWN AND GET CHANGE TO BE MADE AND GET IT DONE FAST. BECAUSE TIME IS NOT SOMETHING WE HAVE IN SACRAMENTO. ERIN HEFT KCRA. THREE NEWS. IN A STATEMENT TO KCRA THREE, KAISER PERMANENTE SAID IN PART, WE RECOGNIZE ANY TIME THERE WAS A NATIONAL SHORTAGE OF MEDICATION LIKE CISPLATIN, THAT PATIENTS WHO ARE AFFECTED MAY FEEL ANXIOUS. WE WANT EVERY PATIENT TO FULLY UNDERSTAND AND BE COMFORTABLE WITH THEIR TREATMENT PLAN. OUR PHYSICIANS AND PHARMACISTS ARE WORKING WITH THEIR PATIENTS TO ENSURE THEIR TREATMENT PLAN IS AS EFFECTIVE
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Cancer centers say US chemotherapy shortage is leading to treatment complications
A growing shortage of common cancer treatments is forcing doctors to switch medications and delaying some care, prominent U.S. cancer centers say.The National Comprehensive Cancer Network said Wednesday that nearly all the centers it surveyed late last month were dealing with shortages of carboplatin and cisplatin, a pair of drugs used to treat a range of cancers. Some are no longer able to treat patients receiving carboplatin at the intended dose or schedule.In the video player above: A patient talks about how his cancer treatment was delayed amid medication shortageDr. Kari Wisinski has had to turn to other treatments for some patients or switch the order in which people receive their drug combinations. She said she's done that "hoping that within three months there will be a better carboplatin supply.""It's really difficult as a physician to have these conversations with a family or a patient about not having a medication you'd like to prescribe to them," she said.Wisinski is a breast cancer specialist with the UW Health Carbone Cancer Center in Madison, Wisconsin, a member of the network. She said doctors, nurses and pharmacists at her center have done a good job managing the drug supply, but doing so has taken them away from other elements of care.Of the 27 cancer centers that responded to the network's survey, 25 reported a shortage of carboplatin. Among the cancer centers with shortages of carboplatin, more than a third said they were unable to treat all patients according to the intended dose and schedule.Nineteen hospitals also reported cisplatin shortages, but all said they were able to maintain the treatments for existing patients.Video below: More about the cancer drug shortageThe problem started developing earlier this year, said Mike Ganio, who studies drug shortages at the American Society of Health-System Pharmacists."I think it went from being a shortage to being a really bad shortage really quickly," he said. "There's not a whole lot of room for it to get worse."Ganio's society reported the cisplatin shortage in January and then carboplatin in late March, months after a factory in India that makes both drugs paused production following an inspection that raised quality concerns.Manufacturing problems, unexpected demand spikes and tight ingredient supplies have all contributed to a growing number of prescription drug shortages in the United States. Many patients with attention deficit/hyperactivity disorder have had a hard time filling prescriptions for Adderall this year, and drugstores ran out of children's medicines during last winter's cold-and-flu season.There were 301 active national drug shortages through this year's first quarter, according to the University of Utah Drug Information Service.The U.S. Food and Drug Administration has taken some steps to try to ease the chemotherapy shortage. The agency is allowing the temporary importation of some foreign-approved versions of cisplatin from factories registered with the FDA.Video below: FDA says over a dozen cancer treatment drugs are under shortageThat should help, but the big factor is getting the factory in India back up to full production, Ganio said.He also noted that drug supply shortages are a decades-old problem."We really need to get at the root causes of these shortages or they're going to continue happening," he said.

A growing shortage of common cancer treatments is forcing doctors to switch medications and delaying some care, prominent U.S. cancer centers say.

The National Comprehensive Cancer Network said Wednesday that nearly all the centers it surveyed late last month were dealing with shortages of carboplatin and cisplatin, a pair of drugs used to treat a range of cancers. Some are no longer able to treat patients receiving carboplatin at the intended dose or schedule.

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In the video player above: A patient talks about how his cancer treatment was delayed amid medication shortage

Dr. Kari Wisinski has had to turn to other treatments for some patients or switch the order in which people receive their drug combinations. She said she's done that "hoping that within three months there will be a better carboplatin supply."

"It's really difficult as a physician to have these conversations with a family or a patient about not having a medication you'd like to prescribe to them," she said.

Wisinski is a breast cancer specialist with the UW Health Carbone Cancer Center in Madison, Wisconsin, a member of the network. She said doctors, nurses and pharmacists at her center have done a good job managing the drug supply, but doing so has taken them away from other elements of care.

Of the 27 cancer centers that responded to the network's survey, 25 reported a shortage of carboplatin. Among the cancer centers with shortages of carboplatin, more than a third said they were unable to treat all patients according to the intended dose and schedule.

Nineteen hospitals also reported cisplatin shortages, but all said they were able to maintain the treatments for existing patients.

Video below: More about the cancer drug shortage

The problem started developing earlier this year, said Mike Ganio, who studies drug shortages at the American Society of Health-System Pharmacists.

"I think it went from being a shortage to being a really bad shortage really quickly," he said. "There's not a whole lot of room for it to get worse."

Ganio's society reported the cisplatin shortage in January and then carboplatin in late March, months after a factory in India that makes both drugs paused production following an inspection that raised quality concerns.

Manufacturing problems, unexpected demand spikes and tight ingredient supplies have all contributed to a growing number of prescription drug shortages in the United States. Many patients with attention deficit/hyperactivity disorder have had a hard time filling prescriptions for Adderall this year, and drugstores ran out of children's medicines during last winter's cold-and-flu season.

There were 301 active national drug shortages through this year's first quarter, according to the University of Utah Drug Information Service.

The U.S. Food and Drug Administration has taken some steps to try to ease the chemotherapy shortage. The agency is allowing the temporary importation of some foreign-approved versions of cisplatin from factories registered with the FDA.

Video below: FDA says over a dozen cancer treatment drugs are under shortage

That should help, but the big factor is getting the factory in India back up to full production, Ganio said.

He also noted that drug supply shortages are a decades-old problem.

"We really need to get at the root causes of these shortages or they're going to continue happening," he said.